Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors

[Image: see text] A series of rhodanines was constructed, their Z-configuration was confirmed by small molecule X-ray crystal structures, and their activity against metallo-β-lactamases (MβLs) was measured. The obtained 26 molecules and a thioenolate specifically inhibited the MβL L1 with an IC(50)...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Xiang, Yang, Chen, Cheng, Wang, Wen-Ming, Xu, Li-Wei, Yang, Ke-Wu, Oelschlaeger, Peter, He, Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900329/
https://ncbi.nlm.nih.gov/pubmed/29670701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00548
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