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Azolylthioacetamide: A Highly Promising Scaffold for the Development of Metallo-β-lactamase Inhibitors
[Image: see text] A new scaffold, azolylthioacetamide, was constructed and assayed against metallo-β-lactamases (MβLs). The obtained molecules specifically inhibited MβL ImiS, and 1c was found to be the most potent inhibitor, with a K(i) = 1.2 μM using imipenem as substrate. Structure–activity relat...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4394341/ https://ncbi.nlm.nih.gov/pubmed/25893049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500534c |
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