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Rhodanine as a Potent Scaffold for the Development of Broad-Spectrum Metallo-β-lactamase Inhibitors
[Image: see text] A series of rhodanines was constructed, their Z-configuration was confirmed by small molecule X-ray crystal structures, and their activity against metallo-β-lactamases (MβLs) was measured. The obtained 26 molecules and a thioenolate specifically inhibited the MβL L1 with an IC(50)...
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| Publicado no: | ACS Med Chem Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2018
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900329/ https://ncbi.nlm.nih.gov/pubmed/29670701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00548 |
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