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meta-Substituted benzenesulfonamide: a potent scaffold for the development of metallo-β-lactamase ImiS inhibitors
Metallo-β-lactamase (MβL) ImiS contributes to the emergence of carbapenem resistance. A potent scaffold, meta-substituted benzenesulfonamide, was constructed and assayed against MβLs. The twenty-one obtained molecules specifically inhibited ImiS (IC(50) = 0.11–9.3 μM); 2g was found to be the best in...
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| Vydáno v: | RSC Med Chem |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Royal Society of Chemistry
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7412727/ https://ncbi.nlm.nih.gov/pubmed/33479632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00455f |
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