A Vitamin B12 Conjugate of Exendin-4 Improves Glucose Tolerance Without Associated Nausea or Hypophagia in Rodents

AIMS: While pharmacological glucagon-like peptide-1 receptor (GLP-1R) agonists are FDA-approved for treating type 2 diabetes mellitus (T2DM) and obesity, a major side effect is nausea/malaise. We recently developed a conjugate of vitamin B12 bound to the GLP-1R agonist exendin-4 (Ex4), which display...

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Publicat a:Diabetes Obes Metab
Autors principals: Mietlicki-Baase, Elizabeth G., Liberini, Claudia G., Workinger, Jayme L., Bonaccorso, Ron L., Borner, Tito, Reiner, David J., Koch-Laskowski, Kieran, McGrath, Lauren E., Lhamo, Rinzin, Stein, Lauren M., De Jonghe, Bart C., Holz, George G., Roth, Christian L., Doyle, Robert P., Hayes, Matthew R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899935/
https://ncbi.nlm.nih.gov/pubmed/29327400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/dom.13222
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