Interleukin-8 mediates neutrophil-endothelial interactions in pig-to-human xenogeneic models

BACKGROUND: Human neutrophils are sequestered by pig lung xenografts within minutes during ex vivo perfusion. This phenomenon is not prevented by pig genetic modifications that remove xeno-antigens or added human regulatory molecules intended to down-regulate activation of complement and coagulation...

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Udgivet i:Xenotransplantation
Main Authors: French, Beth M., Sendil, Selin, Sepuru, Krishna Mohan, Ranek, Jolene, Burdorf, Lars, Harris, Donald, Redding, Emily, Cheng, Xiangfei, Laird, Christopher, Zhao, Yuming, Cerel, Benjamin, Rajarathnam, Krishna, Pierson, Richard N, Azimzadeh, Agnes M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899681/
https://ncbi.nlm.nih.gov/pubmed/29427404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/xen.12385
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