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Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP(2) depletion

Brain capillaries play a critical role in sensing neural activity and translating it into dynamic changes in cerebral blood flow to serve the metabolic needs of the brain. The molecular cornerstone of this mechanism is the capillary endothelial cell inward rectifier K(+) (Kir2.1) channel, which is a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Harraz, Osama F., Longden, Thomas A., Dabertrand, Fabrice, Hill-Eubanks, David, Nelson, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899484/
https://ncbi.nlm.nih.gov/pubmed/29581272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800201115
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