The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K(+)-mediated neurovascular communication

Neuronal activity leads to an increase in local cerebral blood flow (CBF) to allow adequate supply of oxygen and nutrients to active neurons, a process termed neurovascular coupling (NVC). We have previously shown that capillary endothelial cell (cEC) inwardly rectifying K(+) (Kir) channels can sens...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Moshkforoush, Arash, Ashenagar, Baarbod, Harraz, Osama F., Dabertrand, Fabrice, Longden, Thomas A., Nelson, Mark T., Tsoukias, Nikolaos M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368319/
https://ncbi.nlm.nih.gov/pubmed/32601236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000151117
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