A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming

In mice, the PIWI-piRNA pathway is essential to re-establish transposon silencing during male germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2-bound piRNAs and its nuclear localization are proposed to be dep...

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Bibliografski detalji
Izdano u:Nat Struct Mol Biol
Glavni autori: Vasilauskaitė, Lina, Vitsios, Dimitrios, Berrens, Rebecca, Carrieri, Claudia, Reik, Wolf, Enright, Anton J, O’Carroll, Dónal
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898609/
https://ncbi.nlm.nih.gov/pubmed/28530707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3413
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