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A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming
In mice, the PIWI-piRNA pathway is essential to re-establish transposon silencing during male germline reprogramming. The cytoplasmic PIWI protein MILI mediates piRNA-guided transposon RNA cleavage as well as piRNA amplification. MIWI2-bound piRNAs and its nuclear localization are proposed to be dep...
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| Veröffentlicht in: | Nat Struct Mol Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898609/ https://ncbi.nlm.nih.gov/pubmed/28530707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3413 |
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