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Defining information fractions in group sequential clinical trials with multiple endpoints
The group sequential design has been well understood and widely applied in designs of late phase clinical trial to enable potentially early stopping for efficacy or futility. The information fraction (IF) is one of the key elements to determine the decision boundary at the interim analyses. The fami...
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| Publicado no: | Contemp Clin Trials Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898546/ https://ncbi.nlm.nih.gov/pubmed/29696161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2018.03.005 |
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