Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria

BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jeeyapant, Atthanee, Kingston, Hugh W., Plewes, Katherine, Maude, Richard J., Hanson, Josh, Herdman, M. Trent, Leopold, Stije J., Ngernseng, Thatsanun, Charunwatthana, Prakaykaew, Phu, Nguyen Hoan, Ghose, Aniruddha, Hasan, M. Mahtab Uddin, Fanello, Caterina I., Faiz, Md Abul, Hien, Tran Tinh, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215574/
https://ncbi.nlm.nih.gov/pubmed/28052109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169307
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