Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria

BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Jeeyapant, Atthanee, Kingston, Hugh W., Plewes, Katherine, Maude, Richard J., Hanson, Josh, Herdman, M. Trent, Leopold, Stije J., Ngernseng, Thatsanun, Charunwatthana, Prakaykaew, Phu, Nguyen Hoan, Ghose, Aniruddha, Hasan, M. Mahtab Uddin, Fanello, Caterina I., Faiz, Md Abul, Hien, Tran Tinh, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215574/
https://ncbi.nlm.nih.gov/pubmed/28052109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169307
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