Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria

BACKGROUND: Clinical trials in severe falciparum malaria require a large sample size to detect clinically meaningful differences in mortality. This means few interventions can be evaluated at any time. Using a validated surrogate endpoint for mortality would provide a useful alternative allowing a s...

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Publicat a:PLoS One
Autors principals: Jeeyapant, Atthanee, Kingston, Hugh W., Plewes, Katherine, Maude, Richard J., Hanson, Josh, Herdman, M. Trent, Leopold, Stije J., Ngernseng, Thatsanun, Charunwatthana, Prakaykaew, Phu, Nguyen Hoan, Ghose, Aniruddha, Hasan, M. Mahtab Uddin, Fanello, Caterina I., Faiz, Md Abul, Hien, Tran Tinh, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215574/
https://ncbi.nlm.nih.gov/pubmed/28052109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169307
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