Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria

Background. Hyperlactatemia is a strong predictor of mortality in severe falciparum malaria. Sequestered parasitized erythrocytes and reduced uninfected red blood cell deformability (RCD) compromise microcirculatory flow, leading to anaerobic glycolysis. Methods. In a cohort of patients with falcipa...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Ishioka, Haruhiko, Ghose, Aniruddha, Charunwatthana, Prakaykaew, Maude, Richard, Plewes, Katherine, Kingston, Hugh, Intharabut, Benjamas, Woodrow, Charlie, Chotivanich, Kesinee, Sayeed, Abdullah Abu, Hasan, Mahtab Uddin, Day, Nicholas P., Faiz, Abul, White, Nicholas J., Hossain, Amir, Dondorp, Arjen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747623/
https://ncbi.nlm.nih.gov/pubmed/26494775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv502
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