Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study

BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease’s pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...

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Detalhes bibliográficos
Publicado no:BMC Med
Main Authors: Hanson, Josh, Lee, Sue J., Hossain, Md Amir, Anstey, Nicholas M., Charunwatthana, Prakaykaew, Maude, Richard J., Kingston, Hugh W. F., Mishra, Saroj K., Mohanty, Sanjib, Plewes, Katherine, Piera, Kim, Hassan, Mahtab U., Ghose, Aniruddha, Faiz, M. Abul, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453275/
https://ncbi.nlm.nih.gov/pubmed/26018532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0365-9
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