Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study

BACKGROUND: Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease’s pathogenesis and outcome are unknown. METHODS: Microvascular blood flow was quantified in adults with severe falcip...

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Foilsithe in:BMC Med
Main Authors: Hanson, Josh, Lee, Sue J., Hossain, Md Amir, Anstey, Nicholas M., Charunwatthana, Prakaykaew, Maude, Richard J., Kingston, Hugh W. F., Mishra, Saroj K., Mohanty, Sanjib, Plewes, Katherine, Piera, Kim, Hassan, Mahtab U., Ghose, Aniruddha, Faiz, M. Abul, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453275/
https://ncbi.nlm.nih.gov/pubmed/26018532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-015-0365-9
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