Enantioselective Desymmetrization of Methylenedianilines via Enzyme-Catalyzed Remote Halogenation

Extensive effort has been devoted to engineering flavin-dependent halogenases (FDHs) with improved stability, expanded substrate scope, and altered regioselectivity. Here we show that variants of rebeccamycin halogenase (RebH) catalyze enantioselective desymmetrization of methylenedianilines via hal...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Payne, James T., Butkovich, Paul H., Gu, Yifan, Kunze, Kyle N., Park, Hyun June, Wang, Duo-Sheng, Lewis, Jared C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5898188/
https://ncbi.nlm.nih.gov/pubmed/29294291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09573
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