Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

Negative regulation of immune pathways is essential to achieve resolution of immune responses and to avoid excess inflammation. DNA stimulates type I IFN expression through the DNA sensor cGAS, the second messenger cGAMP, and the adaptor molecule STING. Here, we report that STING degradation followi...

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Vydáno v:EMBO J
Hlavní autoři: Prabakaran, Thaneas, Bodda, Chiranjeevi, Krapp, Christian, Zhang, Bao‐cun, Christensen, Maria H, Sun, Chenglong, Reinert, Line, Cai, Yujia, Jensen, Søren B, Skouboe, Morten K, Nyengaard, Jens R, Thompson, Craig B, Lebbink, Robert Jan, Sen, Ganes C, van Loo, Geert, Nielsen, Rikke, Komatsu, Masaaki, Nejsum, Lene N, Jakobsen, Martin R, Gyrd‐Hansen, Mads, Paludan, Søren R
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897779/
https://ncbi.nlm.nih.gov/pubmed/29496741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797858
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