Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Protection of the brain from viral infections involves the type I IFN (IFN-I) system, defects in which render humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels lead to pathologies, suggesting the need for tight regulation of responses. Based on data fr...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Reinert, Line S., Rashidi, Ahmad S., Tran, Diana N., Katzilieris-Petras, Georgios, Hvidt, Astrid K., Gohr, Mette, Fruhwürth, Stefanie, Bodda, Chiranjeevi, Thomsen, Martin K., Vendelbo, Mikkel H., Khan, Ahmad R., Hansen, Brian, Bergström, Petra, Agholme, Lotta, Mogensen, Trine H., Christensen, Maria H., Nyengaard, Jens R., Sen, Ganes C., Zetterberg, Henrik, Verjans, Georges MGM, Paludan, Søren R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773356/
https://ncbi.nlm.nih.gov/pubmed/32990676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136824
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker