Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production

Protection of the brain from viral infections involves the type I IFN (IFN-I) system, defects in which render humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels lead to pathologies, suggesting the need for tight regulation of responses. Based on data fr...

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Pubblicato in:J Clin Invest
Autori principali: Reinert, Line S., Rashidi, Ahmad S., Tran, Diana N., Katzilieris-Petras, Georgios, Hvidt, Astrid K., Gohr, Mette, Fruhwürth, Stefanie, Bodda, Chiranjeevi, Thomsen, Martin K., Vendelbo, Mikkel H., Khan, Ahmad R., Hansen, Brian, Bergström, Petra, Agholme, Lotta, Mogensen, Trine H., Christensen, Maria H., Nyengaard, Jens R., Sen, Ganes C., Zetterberg, Henrik, Verjans, Georges MGM, Paludan, Søren R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773356/
https://ncbi.nlm.nih.gov/pubmed/32990676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI136824
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