Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

Negative regulation of immune pathways is essential to achieve resolution of immune responses and to avoid excess inflammation. DNA stimulates type I IFN expression through the DNA sensor cGAS, the second messenger cGAMP, and the adaptor molecule STING. Here, we report that STING degradation followi...

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Publicado no:EMBO J
Main Authors: Prabakaran, Thaneas, Bodda, Chiranjeevi, Krapp, Christian, Zhang, Bao‐cun, Christensen, Maria H, Sun, Chenglong, Reinert, Line, Cai, Yujia, Jensen, Søren B, Skouboe, Morten K, Nyengaard, Jens R, Thompson, Craig B, Lebbink, Robert Jan, Sen, Ganes C, van Loo, Geert, Nielsen, Rikke, Komatsu, Masaaki, Nejsum, Lene N, Jakobsen, Martin R, Gyrd‐Hansen, Mads, Paludan, Søren R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897779/
https://ncbi.nlm.nih.gov/pubmed/29496741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797858
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