cGAS is activated by DNA in a length‐dependent manner

Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Despite the importance of DNA in innate immunity, the...

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Dettagli Bibliografici
Pubblicato in:EMBO Rep
Autori principali: Luecke, Stefanie, Holleufer, Andreas, Christensen, Maria H, Jønsson, Kasper L, Boni, Gerardo A, Sørensen, Lambert K, Johannsen, Mogens, Jakobsen, Martin R, Hartmann, Rune, Paludan, Søren R
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
Soggetti:
Scientific Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623850/
https://ncbi.nlm.nih.gov/pubmed/28801534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744017
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