cGAS is activated by DNA in a length‐dependent manner

Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Despite the importance of DNA in innate immunity, the...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Luecke, Stefanie, Holleufer, Andreas, Christensen, Maria H, Jønsson, Kasper L, Boni, Gerardo A, Sørensen, Lambert K, Johannsen, Mogens, Jakobsen, Martin R, Hartmann, Rune, Paludan, Søren R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623850/
https://ncbi.nlm.nih.gov/pubmed/28801534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744017
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