cGAS is activated by DNA in a length‐dependent manner

Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP‐AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Despite the importance of DNA in innate immunity, the...

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Dades bibliogràfiques
Publicat a:EMBO Rep
Autors principals: Luecke, Stefanie, Holleufer, Andreas, Christensen, Maria H, Jønsson, Kasper L, Boni, Gerardo A, Sørensen, Lambert K, Johannsen, Mogens, Jakobsen, Martin R, Hartmann, Rune, Paludan, Søren R
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623850/
https://ncbi.nlm.nih.gov/pubmed/28801534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744017
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