The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix

Dysregulated secretion and extracellular activation of TGF-β1 stimulates myofibroblasts to accumulate disordered and stiff extracellular matrix (ECM) leading to fibrosis. Fibronectin immobilizes latent TGF-β-binding protein-1 (LTBP-1) and thus stores TGF-β1 in the ECM. Because the ED-A fibronectin s...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Klingberg, Franco, Chau, Grace, Walraven, Marielle, Boo, Stellar, Koehler, Anne, Chow, Melissa L., Olsen, Abby L., Im, Michelle, Lodyga, Monika, Wells, Rebecca G., White, Eric S., Hinz, Boris
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897715/
https://ncbi.nlm.nih.gov/pubmed/29361522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.201293
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