Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

Integrin-mediated force application induces a conformational change in latent TGF-β1 that leads to the release of the active form of the growth factor from the extracellular matrix (ECM). Mechanical activation of TGF-β1 is currently understood as an acute process that depends on the contractile forc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Klingberg, Franco, Chow, Melissa L., Koehler, Anne, Boo, Stellar, Buscemi, Lara, Quinn, Thomas M., Costell, Mercedes, Alman, Benjamin A., Genot, Elisabeth, Hinz, Boris
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210443/
https://ncbi.nlm.nih.gov/pubmed/25332161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201402006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados