Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

The conjunctive presence of mechanical stress and active transforming growth factor β1 (TGF-β1) is essential to convert fibroblasts into contractile myofibroblasts, which cause tissue contractures in fibrotic diseases. Using cultured myofibroblasts and conditions that permit tension modulation on th...

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Bibliografiska uppgifter
Huvudupphovsmän: Wipff, Pierre-Jean, Rifkin, Daniel B., Meister, Jean-Jacques, Hinz, Boris
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2007
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140013/
https://ncbi.nlm.nih.gov/pubmed/18086923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200704042
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