HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct well-populated conformational states: a pre-trigg...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Ma, Xiaochu, Lu, Maolin, Gorman, Jason, Terry, Daniel S, Hong, Xinyu, Zhou, Zhou, Zhao, Hong, Altman, Roger B, Arthos, James, Blanchard, Scott C, Kwong, Peter D, Munro, James B, Mothes, Walther
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2018
Matèries:
Microbiology and Infectious Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896952/
https://ncbi.nlm.nih.gov/pubmed/29561264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34271
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