Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands

The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer of gp120-gp41 heterodimers mediates virus entry into CD4-positive (CD4(+)) cells. Single-molecule fluorescence resonance energy transfer (smFRET) has revealed that native Env on the surface of viruses predominantly ex...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lu, Maolin, Ma, Xiaochu, Reichard, Nick, Terry, Daniel S., Arthos, James, Smith, Amos B., Sodroski, Joseph G., Blanchard, Scott C., Mothes, Walther
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431789/
https://ncbi.nlm.nih.gov/pubmed/32522853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00597-20
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