HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct well-populated conformational states: a pre-trigg...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Ma, Xiaochu, Lu, Maolin, Gorman, Jason, Terry, Daniel S, Hong, Xinyu, Zhou, Zhou, Zhao, Hong, Altman, Roger B, Arthos, James, Blanchard, Scott C, Kwong, Peter D, Munro, James B, Mothes, Walther
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2018
Fag:
Microbiology and Infectious Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896952/
https://ncbi.nlm.nih.gov/pubmed/29561264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34271
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