HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct well-populated conformational states: a pre-trigg...

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書目詳細資料
發表在:eLife
Main Authors: Ma, Xiaochu, Lu, Maolin, Gorman, Jason, Terry, Daniel S, Hong, Xinyu, Zhou, Zhou, Zhao, Hong, Altman, Roger B, Arthos, James, Blanchard, Scott C, Kwong, Peter D, Munro, James B, Mothes, Walther
格式: Artigo
語言:Inglês
出版: eLife Sciences Publications, Ltd 2018
主題:
Microbiology and Infectious Disease
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896952/
https://ncbi.nlm.nih.gov/pubmed/29561264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34271
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