HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env trimers to be dynamic, spontaneously transitioning between three distinct well-populated conformational states: a pre-trigg...

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Veröffentlicht in:eLife
Hauptverfasser: Ma, Xiaochu, Lu, Maolin, Gorman, Jason, Terry, Daniel S, Hong, Xinyu, Zhou, Zhou, Zhao, Hong, Altman, Roger B, Arthos, James, Blanchard, Scott C, Kwong, Peter D, Munro, James B, Mothes, Walther
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Microbiology and Infectious Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896952/
https://ncbi.nlm.nih.gov/pubmed/29561264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34271
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