Identification of Structural and Molecular Features Involved in the Transport of 3′-Deoxy-Nucleoside Analogs by Human Equilibrative Nucleoside Transporter 3

Combination antiretroviral drug treatments depend on 3′-deoxy-nucleoside analogs such as 3′-azido-3′-deoxythymidine (AZT) and 2′3′-dideoxyinosine (DDI). Despite being effective in inhibiting human immunodeficiency virus replication, these drugs produce a range of toxicities, including myopathy, panc...

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Vydáno v:Drug Metab Dispos
Hlavní autoři: Rahman, MD Fazlur, Raj, Radhika, Govindarajan, Rajgopal
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Special Section on Transporters in Drug Disposition and Pharmacokinetic Prediction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896370/
https://ncbi.nlm.nih.gov/pubmed/29530865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.079400
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