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Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

human equilibrative nucleoside transporter-3 (hENT3) was recently reported as a pH-dependent, intracellular (lysosomal) transporter capable of transporting anti-human immunodeficiency virus (HIV) dideoxynucleosides (ddNs). Because most anti-HIV ddNs (e.g., zidovudine, AZT) exhibit clinical mitochond...

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Main Authors: Govindarajan, Rajgopal, Leung, George P. H., Zhou, Mingyan, Tse, Chung-Ming, Wang, Joanne, Unadkat, Jashvant D
格式: Artigo
語言:Inglês
出版: American Physiological Society 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670673/
https://ncbi.nlm.nih.gov/pubmed/19164483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90672.2008
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