The Role of the Equilibrative Nucleoside Transporter 1 (ENT1) in Transport and Metabolism of Ribavirin by Human and Wild-Type or Ent1(-/-) Mouse Erythrocytes

The polar nucleoside drug ribavirin is front-line treatment for chronic hepatitis C virus infection. The human equilibrative nucleoside transporter (ENT) 1 transports ribavirin into erythrocytes where it is phosphorylated. These phosphorylated metabolites accumulate in the erythrocytes and produce d...

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Autores principales: Endres, Christopher J., Moss, Aaron M., Ke, Ban, Govindarajan, Rajgopal, Choi, Doo-Sup, Messing, Robert O., Unadkat, Jashvant D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Pharmacology and Experimental Therapeutics 2009
Materias:
Metabolism, Transport, and Pharmacogenomics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670593/
https://ncbi.nlm.nih.gov/pubmed/19164463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.145854
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