Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

BACKGROUND: Neuroinflammation plays an important role in the pathogenesis of intracerebral hemorrhage (ICH)-induced secondary brain injury. Activation of melanocortin receptor 4 (MC4R) has been shown to elicit anti-inflammatory effects in many diseases. The objective of this study was to explore the...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Chen, Shengpan, Zhao, Lianhua, Sherchan, Prativa, Ding, Yan, Yu, Jing, Nowrangi, Derek, Tang, Jiping, Xia, Ying, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896146/
https://ncbi.nlm.nih.gov/pubmed/29642894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1140-6
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