The MC(4) receptor agonist RO27‐3225 inhibits NLRP1‐dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage

BACKGROUND AND PURPOSE: Inflammasome‐mediated pyroptosis is an important neuronal cell death mechanism. Previous studies reported that activation of melanocortin MC(4) receptor exerted neuroprotection in several neurological diseases. Here, we have investigated the role of MC(4) receptor activation...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Chen, Shengpan, Zuo, Yuchun, Huang, Lei, Sherchan, Prativa, Zhang, Jian, Yu, Zhengtao, Peng, Jianhua, Zhang, Junyi, Zhao, Lianhua, Doycheva, Desislava, Liu, Fei, Zhang, John H., Xia, Ying, Tang, Jiping
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6468256/
https://ncbi.nlm.nih.gov/pubmed/30811584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14639
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