Effects of Partially Dismantling the CD4 Binding Site Glycan Fence of HIV-1 Envelope Glycoprotein Trimers on Neutralizing Antibody Induction

Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to i...

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Bibliographic Details
Published in:Virology
Main Authors: Crooks, Ema T., Osawa, Keiko, Tong, Tommy, Grimley, Samantha L., Dai, Yang D., Whalen, Robert G., Kulp, Daniel W., Menis, Sergey, Schief, William R., Binley, James M.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895097/
https://ncbi.nlm.nih.gov/pubmed/28279830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.02.024
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