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Effects of Partially Dismantling the CD4 Binding Site Glycan Fence of HIV-1 Envelope Glycoprotein Trimers on Neutralizing Antibody Induction
Previously, VLPs bearing JR-FL strain HIV-1 Envelope trimers elicited potent neutralizing antibodies (nAbs) in 2/8 rabbits (PLoS Pathog 11(5): e1004932) by taking advantage of a naturally absent glycan at position 197 that borders the CD4 binding site (CD4bs). In new immunizations, we attempted to i...
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| Veröffentlicht in: | Virology |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5895097/ https://ncbi.nlm.nih.gov/pubmed/28279830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.02.024 |
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