Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Sorrells, Shelly, Nik, Sara, Casey, Mattie, Cameron, Rosannah C., Truong, Harold, Toruno, Cristhian, Gulfo, Michelle, Lowe, Albert, Jette, Cicely, Stewart, Rodney A., Bowman, Teresa V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894942/
https://ncbi.nlm.nih.gov/pubmed/29419415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031583
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