Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Sorrells, Shelly, Nik, Sara, Casey, Mattie, Cameron, Rosannah C., Truong, Harold, Toruno, Cristhian, Gulfo, Michelle, Lowe, Albert, Jette, Cicely, Stewart, Rodney A., Bowman, Teresa V.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894942/
https://ncbi.nlm.nih.gov/pubmed/29419415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031583
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