Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. Th...

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Publicat a:Dis Model Mech
Autors principals: Sorrells, Shelly, Nik, Sara, Casey, Mattie, Cameron, Rosannah C., Truong, Harold, Toruno, Cristhian, Gulfo, Michelle, Lowe, Albert, Jette, Cicely, Stewart, Rodney A., Bowman, Teresa V.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894942/
https://ncbi.nlm.nih.gov/pubmed/29419415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031583
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