Post-transcriptional Regulation of UGT2B10 Hepatic Expression and Activity by Alternative Splicing

The detoxification enzyme UDP-glucuronosyltransferase UGT2B10 is specialized in the N-linked glucuronidation of many drugs and xenobiotics. Preferred substrates possess tertiary aliphatic amines and heterocyclic amines, such as tobacco carcinogens and several antidepressants and antipsychotics. We h...

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Udgivet i:Drug Metab Dispos
Main Authors: Labriet, Adrien, Allain, Eric P., Rouleau, Michèle, Audet-Delage, Yannick, Villeneuve, Lyne, Guillemette, Chantal
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894810/
https://ncbi.nlm.nih.gov/pubmed/29438977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.079921
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