Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo

A cell therapy platform permitting long-term delivery of peptide hormones in vivo would be a significant advance for patients with hormonal deficiencies. Here we report the utility of antigen-specific T lymphocytes as a regulatable peptide delivery platform for in vivo therapy. piggyBac transposon m...

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Udgivet i:Nat Commun
Main Authors: O’Neil, Richard T., Saha, Sunandan, Veach, Ruth Ann, Welch, Richard C., Woodard, Lauren E., Rooney, Cliona M., Wilson, Matthew H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893599/
https://ncbi.nlm.nih.gov/pubmed/29636469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03787-8
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