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Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes

The piggyBac transposon system is a promising nonviral method to genetically modifiy T cells for immunotherapeutic applications. To evaluate the regulation and stability of transgene expression in human T cells modified with piggyBac transposons, peripheral blood mononuclear cells (PBMCs) were nucle...

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Detalhes bibliográficos
Main Authors: Nakazawa, Yozo, Saha, Sunandan, Galvan, Daniel L., Huye, Leslie, Rollins, Lisa, Rooney, Cliona M., Wilson, Matthew H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521868/
https://ncbi.nlm.nih.gov/pubmed/23211626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182791234
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