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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients
Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutati...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5893593/ https://ncbi.nlm.nih.gov/pubmed/29636477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03867-9 |
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