Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients

Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutati...

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發表在:Nat Commun
Main Authors: Chen, Li, Yang, Liu, Yao, Ling, Kuang, Xia-Ying, Zuo, Wen-Jia, Li, Shan, Qiao, Feng, Liu, Yi-Rong, Cao, Zhi-Gang, Zhou, Shu-Ling, Zhou, Xiao-Yan, Yang, Wen-Tao, Shi, Jin-Xiu, Huang, Wei, Hu, Xin, Shao, Zhi-Ming
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893593/
https://ncbi.nlm.nih.gov/pubmed/29636477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03867-9
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