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Selective inhibition of histamine-evoked Ca(2+) signals by compartmentalized cAMP in human bronchial airway smooth muscle cells

Intracellular Ca(2+) and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the interactions between different G protein-coupled receptors (GPCRs) tha...

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Publicat a:Cell Calcium
Autors principals: Dale, Philippa, Head, Victoria, Dowling, Mark R., Taylor, Colin W.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893132/
https://ncbi.nlm.nih.gov/pubmed/29604964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2017.12.002
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