Sonic hedgehog signaling in spinal cord contributes to morphine-induced hyperalgesia and tolerance through upregulating brain-derived neurotrophic factor expression

PURPOSE: Preventing opioid-induced hyperalgesia and tolerance continues to be a major clinical challenge, and the underlying mechanisms of hyperalgesia and tolerance remain elusive. Here, we investigated the role of sonic hedgehog (Shh) signaling in opioid-induced hyperalgesia and tolerance. METHODS...

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Detalhes bibliográficos
Publicado no:J Pain Res
Main Authors: Liu, Su, Yao, Jun-Li, Wan, Xin-Xin, Song, Zhi-Jing, Miao, Shuai, Zhao, Ye, Wang, Xiu-Li, Liu, Yue-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892616/
https://ncbi.nlm.nih.gov/pubmed/29662325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S153544
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