Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats

Analgesic tolerance and hyperalgesia hinder the long-term utility of opioids. We examined whether spinal high mobility group box 1 (HMGB1) is involved in morphine tolerance and its underlying mechanisms by using a model of repeated intrathecal (i.t.) injections of morphine. The results showed that c...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Qian, Junliang, Zhu, Yanan, Bai, Liying, Gao, Yan, Jiang, Mingjun, Xing, Fei, Zhang, Jian, Zhao, Wenchao, Gu, Hanwen, Mi, Yang, Tao, Yuan-Xiang, Xu, Ji-Tian
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7283437/
https://ncbi.nlm.nih.gov/pubmed/31879851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-019-00800-w
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