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Proteomic Analysis of PKCγ-Related Proteins in the Spinal Cord of Morphine-Tolerant Rats

BACKGROUND: Morphine tolerance is a common drawback of chronic morphine exposure, hindering use of this drug. Studies have shown that PKCã may play a key role in the development of morphine tolerance, although the mechanisms are not fully known. METHODOLOGY/PRINCIPAL FINDINGS: In a rat model of morp...

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Detalhes bibliográficos
Main Authors: Song, Zongbin, Guo, Qulian, Zhang, Jie, Li, Maoyu, Liu, Chang, Zou, Wangyuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409149/
https://ncbi.nlm.nih.gov/pubmed/22860055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042068
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