SYK inhibition blocks proliferation and migration of glioma cells and modifies the tumor microenvironment

BACKGROUND: Glioblastoma (GBM) is one of the most aggressive human brain tumors, with a median survival of 15–18 months. There is a desperate need to find novel therapeutic targets. Various receptor protein kinases have been identified as potential targets; however, response rates in clinical studie...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Moncayo, Gerald, Grzmil, Michal, Smirnova, Tatiana, Zmarz, Pawel, Huber, Roland M, Hynx, Debby, Kohler, Hubertus, Wang, Yuhua, Hotz, Hans-Rudolf, Hynes, Nancy E, Keller, Georg, Frank, Stephan, Merlo, Adrian, Hemmings, Brian A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892144/
https://ncbi.nlm.nih.gov/pubmed/29401256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy008
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