MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas

High levels of mammalian target of rapamycin complex 1 (mTORC1) activity in malignant gliomas promote tumor progression, suggesting that targeting mTORC1 has potential as a therapeutic strategy. Remarkably, clinical trials in patients with glioma revealed that rapamycin analogs (rapalogs) have limit...

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Detalhes bibliográficos
Main Authors: Grzmil, Michal, Huber, Roland M., Hess, Daniel, Frank, Stephan, Hynx, Debby, Moncayo, Gerald, Klein, Dominique, Merlo, Adrian, Hemmings, Brian A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904612/
https://ncbi.nlm.nih.gov/pubmed/24401275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70198
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