Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer

Androgen receptor (AR) mediates the growth of prostate cancer (PCa) throughout its course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-resistant disease. AR stabilization by androgens makes it distinct from other steroid receptors, which are typicall...

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Publicat a:Cancer Res
Autors principals: Ponnusamy, Suriyan, Coss, Christopher C., Thiyagarajan, Thirumagal, Watts, Kate, Hwang, Dong-Jin, He, Yali, Selth, Luke A., McEwan, Iain J., Duke, Charles B., Pagadala, Jayaprakash, Singh, Geetika, Wake, Robert W., Ledbetter, Christopher, Tilley, Wayne D., Moldoveanu, Tudor, Dalton, James T., Miller, Duane D., Narayanan, Ramesh
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890913/
https://ncbi.nlm.nih.gov/pubmed/28978635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0976
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