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Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer

We report herein the design, synthesis, and pharmacological characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-antagonists that exert broad-scope AR antagonism. Pharmacological evaluation demonstrated that introducing a pyra...

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Publicat a:J Med Chem
Autors principals: He, Yali, Hwang, Dong-Jin, Ponnusamy, Suriyan, Thiyagarajan, Thirumagal, Mohler, Michael L., Narayanan, Ramesh, Miller, Duane D.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703681/
https://ncbi.nlm.nih.gov/pubmed/33095584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00943
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