Novel selective agents for the degradation of androgen receptor variants to treat castration-resistant prostate cancer

Androgen receptor (AR) mediates the growth of prostate cancer (PCa) throughout its course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-resistant disease. AR stabilization by androgens makes it distinct from other steroid receptors, which are typicall...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Ponnusamy, Suriyan, Coss, Christopher C., Thiyagarajan, Thirumagal, Watts, Kate, Hwang, Dong-Jin, He, Yali, Selth, Luke A., McEwan, Iain J., Duke, Charles B., Pagadala, Jayaprakash, Singh, Geetika, Wake, Robert W., Ledbetter, Christopher, Tilley, Wayne D., Moldoveanu, Tudor, Dalton, James T., Miller, Duane D., Narayanan, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890913/
https://ncbi.nlm.nih.gov/pubmed/28978635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0976
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