Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation

Since induced regulatory T cells (iTregs) can be produced in a large quantity in vitro, these cells are expected to be clinically useful to induce immunological tolerance in various immunological diseases. Foxp3 (Forkhead box P3) expression in iTregs is, however, unstable due to the lack of demethyl...

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Detalhes bibliográficos
Publicado no:Int Immunol
Main Authors: Someya, Kazue, Nakatsukasa, Hiroko, Ito, Minako, Kondo, Taisuke, Tateda, Kenn-ichi, Akanuma, Takashi, Koya, Ikuko, Sanosaka, Tsukasa, Kohyama, Jun, Tsukada, Yu-ichi, Takamura-Enya, Takeji, Yoshimura, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890887/
https://ncbi.nlm.nih.gov/pubmed/29048538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxx049
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