Hydrogen Sulfide Promotes Tet1- and Tet2-mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

Regulatory T (Treg) cells are essential for maintenance of immune homeostasis. Here we found that hydrogen sulfide (H(2)S) was required for Foxp3(+) Treg cell differentiation and function, and that H(2)S deficiency led to systemic autoimmune disease. H(2)S maintained expression of methylcytosine dio...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Yang, Ruili, Qu, Cunye, Zhou, Yu, Konkel, Joanne, Shi, Shihong, Liu, Yi, Chen, Chider, Liu, Shiyu, Liu, Dawei, Chen, Yibu, Zandi, Ebrahim, Chen, Wanjun, Zhou, Yanheng, Shi, Songtao
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4731232/
https://ncbi.nlm.nih.gov/pubmed/26275994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.017
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