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Hydrogen Sulfide Promotes Tet1- and Tet2-mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis
Regulatory T (Treg) cells are essential for maintenance of immune homeostasis. Here we found that hydrogen sulfide (H(2)S) was required for Foxp3(+) Treg cell differentiation and function, and that H(2)S deficiency led to systemic autoimmune disease. H(2)S maintained expression of methylcytosine dio...
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| Wydane w: | Immunity |
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| Główni autorzy: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4731232/ https://ncbi.nlm.nih.gov/pubmed/26275994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.017 |
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